VICTORIA

Short Description

Trial of MK-1242 (vericiguat) in subjects with heart failure with reduced EF

VICTORIA: A randomized, placebo-controlled, parallel-group, multi-centered, double-blind, event driven trial of MK-1242 (vericiguat) in subjects with heart failure with reduced ejection fraction (HFrEF).  The safety and efficacy of MK-1242 (vericiguat) compared to placebo, on a background of standard of care will be evaluated.  Vericiguat is a novel oral soluble guanylate cyclase stimulator in development for chronic HF.

• Must have a previous HF hospitalization within 6 months prior to randomization or IV diuretic treatment for HF (without hospitalization) within 3 months prior to randomization.
• Have a history of chronic HF (NYHA class II – IV) on standard therapy before qualifying  HF decompensation
• Have BNP of ≥ 300 pg/ml if in sinus rhythm, ≥ 500 pg/ml if in atrial fibrillation
• Have a LVEF of < 45% assessed within 12 months prior to randomization
• Cannot be taking a PDE5 inhibitor,
• No continuous IV infusion of an inotrope, not on heart transplant list or has/anticipates receiving an ventricular assist device
• NO ACS or coronary revascularization within 60 days of randomization, or has indication for revascularization at time of randomization

Questions: Call Mary Soltau 303-703-2191 or Rebecca Wimmer 303-715-2275

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South Denver Cardiology

Randy Cupps Graduated from Western Colorado University in Gunnison, Colorado, in 1983 with a degree in Physical Education with an emphasis in Exercise Physiology. Randy started his medical career in 1980 as an Emergency Medical Technician (EMT) working on an ambulance and in an emergency room. He then joined South Denver Cardiology in 1986 when it was South Denver Cardiac Rehabilitation as an Exercise Physiologist conducting a wide variety of Graded Exercise Testing on a diverse patient population. Randy continues to keep his EMT current, and he is certified by the American College of Sports Medicine as a Clinical Exercise Physiologist. In 2012 Randy acquired the role of business development, marketing, and physician relations manager at SDCA.

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