REATA

Short Description

Study of the efficacy and safety of Bardoxolone Methyl in patients with PAH.

REATA:  Dose-ranging study of the efficacy and safety of Bardoxolone Methyl in patients with pulmonary arterial hypertension.  The molecular and pharmacologic effects of bardoxolone methyl are broad through its induction of Nrf2 and suppression of NF-κB. Bardoxolone methyl may therefore address multiple facets of the pathophysiology of PAH because it suppresses activation of pro-inflammatory mediators, reduces pathologic endothelin signaling, enhances endothelial nitric oxide (NO) bioavailability, suppresses vascular proliferation, and prevents maladaptive remodeling. Furthermore, while existing therapies primarily target only smooth muscle cells, bardoxolone methyl targets multiple cell types relevant to PAH, including endothelial cells, smooth muscle cells, and macrophages.

• Ages 18 to 75
• Must have symptomatic pulmonary arterial hypertension WHO/NYHA FC class II and II.
• Needs one of the following subtypes of WHO Group 1 PAH: idiopathic or heritable PAH, PAH associated with connective tissue disease, PAH associated with simple, congenital systemic-to-pulmonary shunts at least 1 year following shunt repair, PAH associated with anorexigens or PAH associated with HIV.
• Has had a right heart cath within 12 month of screening visit: PAP ≥ 25 mm Hg, PCWP ≤ 15 mm Hg and PVR > 240 dyn.sec/cm5 or > 3 mm Hg/L/minute.
• BNP level must be ≤ 200 pg/ml

Questions: Call Mary Soltau 303-703-2191 or Rebecca Wimmer 303-715-2275

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South Denver Cardiology

Randy Cupps Graduated from Western Colorado University in Gunnison, Colorado, in 1983 with a degree in Physical Education with an emphasis in Exercise Physiology. Randy started his medical career in 1980 as an Emergency Medical Technician (EMT) working on an ambulance and in an emergency room. He then joined South Denver Cardiology in 1986 when it was South Denver Cardiac Rehabilitation as an Exercise Physiologist conducting a wide variety of Graded Exercise Testing on a diverse patient population. Randy continues to keep his EMT current, and he is certified by the American College of Sports Medicine as a Clinical Exercise Physiologist. In 2012 Randy acquired the role of business development, marketing, and physician relations manager at SDCA.

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