GENETIC-AF

Short Description

Effectiveness trial of bucindolol and Toprol-XL for prevention of symptomatic AF

GENETIC-AF: A genotype-directed comparative effectiveness trial of bucindolol and Toprol-XL for prevention of symptomatic AF/AFL in patients with heart failure. The goal of this study is to demonstrate the superiority of pharmacogenetically targeted bucindolol compared to metoprolol for the prevention of symptomatic AF/AFL in a genotype-defined B1389Arg/Arg HFREF population at high risk of AF/AFL recurrence.

• Must possess the B1389Arg/Arg genotype
• Most recent LVEF <0.50 assessed ≤12 months of Screening Visit
• At least one symptomatic paroxysmal or persistent AF episode ≤ 120 days of screening visit, documented by ECG, Holter, TTM or implanted device.
• Must be clinically appropriate for ECV if AF/AFL is present 3 weeks after study drug initiation.
• Must be clinically euvolemic
• No history of AV node ablation
• No MI, unstable angina, ACS, cardiac surgery or PTCA or evidence of new ischemic changes ≤ to 90 days of the Randomization Visit

Questions: Call Mary Soltau 303-703-2191 or Rebecca Wimmer 303-715-2275

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South Denver Cardiology

Randy Cupps Graduated from Western Colorado University in Gunnison, Colorado, in 1983 with a degree in Physical Education with an emphasis in Exercise Physiology. Randy started his medical career in 1980 as an Emergency Medical Technician (EMT) working on an ambulance and in an emergency room. He then joined South Denver Cardiology in 1986 when it was South Denver Cardiac Rehabilitation as an Exercise Physiologist conducting a wide variety of Graded Exercise Testing on a diverse patient population. Randy continues to keep his EMT current, and he is certified by the American College of Sports Medicine as a Clinical Exercise Physiologist. In 2012 Randy acquired the role of business development, marketing, and physician relations manager at SDCA.

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