August 2010 (revised 8.16.10)

Study Type	Antiplatelet Therapy and Stent
Title	CYPRESS:  A Prospective, Randomized, Multi-Center, Double Blind Trial to Assess the Effectiveness and Safety of Different Durations of Dual Anti-Platelet Therapy in Subjects Undergoing Percutaneous Coronary Intervention with the CYPHER Sirolimus-eluting Coronary Stent.
Study Aim	The purpose of this study is to collect data in subjects with coronary artery disease who were treated with a CYPER stent.  In addition, the data gathered from this study will be combined with other subject data that has been collected in studies utilizing different drug eluting stents.  This information will be studied to determine how long patients should remain on a blood thinner (aspirin) and a second medication that prevents your blood form clotting clopidogrel (Plavix) or prasugrel (Effient) anti-platelet therapy.  Platelets are particles that help the blood to clot.

Study Type	Atrial Fibrillation
Title	Amplatzer Cardiac Plug
Study Aim	The Amplatzer Cardiac Plug is a percutaneous transcatheter device intended to prevent thrombus embolization from the left atrial appendage  (LAA) in subjects who have nonvalvular atrial fibrillation.

Study Type	Atrial Fibrillation and Stroke
Title	CRYSTAL AF:  Cryptogenic Stroke And Underlying AF
Study Aim	The purpose of this study is to compare the continuous monitoring by the Reveal XT Insert able Cardiac Monitor to standard of care optimal medical treatment in subjects after diagnosis of cryptogenic stroke.  This clinical trial will assess the incidence of atria fibrillation in subjects with a recent cryptogenic stroke or transient ischemic attack who are at an increased risk of cardiac arrhythmia, and aims to demonstrate the benefit of timely atrial fibrillation detection for patient care.

Study Type	Lovenox Bridge
Title	BRIDGE--Bridging Anticoagulation in Patients who Require Temporary Interruption of Warfarin Therapy for an Elective Invasive Procedure or Surgery
Study Aim	Compares the efficacy of bridging anticoagulation with no bridging anticoagulation on the rate of thrombosis or bleeding in patients with atrial fibrillation or atrial flutter who require temporary interruption of warfarin.

Study Type	Patent Foramen Ovale and Migraine
Title	PREMIUM--Prospective Randomized investigation to Evaluate incidence of headache reduction in subjects with Migraine and PFO Using the Amplatzer PFO Occluder to Medical Management.
Study Aim	Evaluate whether percutaneous PFO closure is effective in reducing the incidence of disabling migraine headaches in subjects who are refractory to medical treatment.

Study Type	Patent Foramen Ovale and Stroke
Title	RESPECT: Randomized Evaluation of Recurrent Stroke comparing PFO Closure to Established Current Standard of Care Treatment
Study Aim	The purpose of this research study is to compare the AMPLATZER PFO Occluder device to medicine in preventing another stroke related to a PFO and also to evaluate the safety of the study device.